Extensive colitis associated with ixekizumab.

We present the clinical case of a 56-year-old former smoker female, with a family history of maternal ulcerative colitis and personal history of ankylosing spondylitis treated with Ixekizumab for 3 months, who was admitted for fever, left iliac fossa pain and diarrhea without pathological products of 2 weeks of evolution. Abdominopelvic computed tomography scan identified pancolitis. Complete colonoscopy revealed continuous involvement of the proximal colon (right and transverse colon presented deep ulcerations and mucosal friability) with preservation of the terminal ileum. After many complementary tests and according to the clinical context, the diagnosis of extensive colitis associated with IL-17 inhibitor was established.

Extraosseous Ewing's sarcoma of the pancreas.

We present the clinical case of a 21-year-old male with abdominal pain in the left hypochondrium radiating to the ipsilateral lumbar area and a weight loss of 2kg over a month, secondary to a large palpable intra-abdominal mass in the examination. TAC revealed a large solid mass with necrotic-cystic component which depended of the pancreas, infiltrated the spleen, enveloped the celiac trunk and affected to the splenic vases. Inmunohistochemical and molecular study confirmed the diagnosis extraosseus Ewing sarcoma (EES).

Dysphagia secondary to neuroendocrine carcinoma: a rare esophageal tumor.

We present two clinical cases, a 68-year-old male and a 55-year-old female, who are being studied for progressive solid food dysphagia. The initial gastroscopy revealed a polypoid lesion in the first case and a partially stenosing lesion in the second case. Both lesions were located in the mid-esophagus and presented a normal mucosa. Histological diagnosis confirmed an esophageal neuroendocrine carcinoma (NEC) of large cell and small cell types, respectively.

Recambio valvular aórtico mediante prótesis sin sutura en pacientes con estenosis aórtica grave y alto riesgo quirúrgico: revisión sistemática / Sutureless aortic valve replacement for high surgical risk patients with aortic stenosis: systematic review

El recambio valvular aórtico mediante prótesis sin sutura se plantea como un tratamiento alternativo para pacientes con estenosis aórtica grave y alto riesgo quirúrgico. Este trabajo presenta los resultados de una revisión sistemática destinada a evaluar la efectividad y seguridad de este procedimiento. Se identificaron 6 estudios prospectivos, sin grupo de comparación. Cuatro evalúan el modelo ATS 3f Enable® y dos el Perceval S. Los resultados muestran buenos resultados hemodinámicos y clínicos para ambas prótesis. El porcentaje de éxito de implantación de las válvulas ATS 3f Enable® registrado fue superior al 85% y el tiempo medio de bypass cardiopulmonar (BCP) varió entre los 58 y 85 minutos. La implantación de las Perceval S fue exitosa en todos los pacientes y el tiempo medio de BCP inferior a 30 minutos. Dado que no se tienen resultados a largo plazo, se desconoce la durabilidad de las prótesis y las complicaciones tardías (AU)

Sutureless aortic valve replacement is perceived to be an alternative treatment for high surgical riskpatients with severe aortic stenosis. This work presents the results of a systematic review undertaken toassess the effectiveness and safety of this procedure. Eight low quality case series were identified. Sixfocused on prosthesis ATS 3f Enable1and 2 on Perceval S. Results show good haemodynamic and clinicalresults for both prosthesis. Implantation of ATS 3f Enable1valves was successful in more than 85% of thepatients and the mean cardiopulmonary bypass (BCP) time ranged from 58 to 85 minutes. For Perceval S,implantation was successful in all patients and the mean BCP time was less than 30 minutes. Since thereare no long term follow-up studies, the durability of the prosthesis and the appearance of latecomplications is uncertain (AU)

[Sutureless aortic valve replacement for high surgical risk patients with aortic stenosis: systematic review]. / Recambio valvular aórtico mediante prótesis sin sutura en pacientes con estenosis aórtica grave y alto riesgo quirúrgico: revisión sistemática.

Sutureless aortic valve replacement is perceived to be an alternative treatment for high surgical risk patients with severe aortic stenosis. This work presents the results of a systematic review undertaken to assess the effectiveness and safety of this procedure. Eight low quality case series were identified. Six focused on prosthesis ATS 3f Enable(®) and 2 on Perceval S. Results show good haemodynamic and clinical results for both prosthesis. Implantation of ATS 3f Enable(®) valves was successful in more than 85% of the patients and the mean cardiopulmonary bypass (BCP) time ranged from 58 to 85 minutes. For Perceval S, implantation was successful in all patients and the mean BCP time was less than 30 minutes. Since there are no long term follow-up studies, the durability of the prosthesis and the appearance of late complications is uncertain.